Hi Steven,

Thank you for contacting Mearto with your appraisal inquiry.
As you can imagine, works signed by JFK when he was a Senator are not nearly as valuable as those signed when he was President. Also, generally of more interest to collectors are documents that refer to either historically important events or personal matters - this appears to be some a professional correspondence of which there are likely dozens if not hundreds of such documents. Here is a link I used to research this letter and values achieved (recently) at auction for Senator John Kennedy papers: https://www.liveauctioneers.com/search/?keyword=senator%20jack%20kennedy&page=1&pageSize=24&sort=-relevance&status=archive
Based on the photos and information provided, and subject to examination, this is:

A John Fitgerald Kennedy 1954 Typed Letter Signed
on US Senate letterlead
dated February 24, 1954 and addressed to Vice Admiral James L. Holloway in reference to Nicholas DeLuca. With script notations and routing stamps throughout
(DIMENSIONS)
CONDITION: framed
$600-900*
*represents a fair-market value for auction purposes; retail or asking price may vary.

Please let us know if you have additional items to appraise, and thank you again for using Mearto.