Hi Cindy,

Thank you for contacting Mearto with your appraisal inquiry.
The brown material used for the handle could be horn (more likely) or wood(less likely), it's hard for me to tell in the photos...
Based on the photos and information provided, and subject to examination, this is:

A Native American beaded and fringed hide and horn medicine bag
Great Plains, early 20th Century
Of rectangular beaded form, rounded at the bottom, the bag issuing fringe, suspended from a horn and silver beaded handle.
Body of the bag measures 6 inches high by 4 inches wide, not including handle or fringe
PROVENANCE: acquired at an antique store
$150-250*
*represents a fair-market value for auction purposes; retail or asking price may vary.